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| Nomenclature |
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Symbol:
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Cd38tm1Lnd
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Name:
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CD38 antigen;
targeted mutation 1, Frances E Lund
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MGI ID: |
MGI:1861803 |
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Synonyms: |
CD38-, CD38null |
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Gene:
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Cd38
Location:
Chr5:43868809-43912375 bp, + strand
Genetic Position: Chr5,
23.85 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:49170
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 2 and 3, which encode the putative active site of the encoded protein. Homozygous mice lacked transcripts derived from this allele (data not shown). Flow cytometry analysis on splenocytes derived from homozygous mice confirmed that no detectable protein was expressed on the cell surface. (J:49170)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:49170
Cockayne DA et al.,
"Mice deficient for the ecto-nicotinamide adenine dinucleotide"
Blood 1998 Aug 15;92(4):1324-33
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All: |
37 reference(s)
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Analysis Tools
