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| Nomenclature |
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Symbol:
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Acvr2atm1Zuk
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Name:
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activin receptor IIA;
targeted mutation 1, Martin M Matzuk
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MGI ID: |
MGI:1861779 |
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Synonyms: |
actRcIIm1, Acvr2- |
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Gene:
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Acvr2a
Location:
Chr2:48814109-48903269 bp, + strand
Genetic Position: Chr2,
28.38 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:23924
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Parent Cell Line:
| AB2.1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-hprt minigene replaced a genomic fragment containing the initiation codon and the sequences encoding the signal peptide. Northern blot analysis indicated that no transcript was detectable in liver of homozygous mice. (J:23924)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:23924
Matzuk MM et al.,
"Different phenotypes for mice deficient in either activins or activin receptor type II [see comments]"
Nature 1995 Mar 23;374(6520):356-60
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All: |
9 reference(s)
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Analysis Tools
