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| Nomenclature |
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Symbol:
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Abcd1tm1Kan
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Name:
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ATP-binding cassette, sub-family D (ALD), member 1;
targeted mutation 1, Klaus-Armin Nave
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MGI ID: |
MGI:1861771 |
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Synonyms: |
ald - |
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Gene:
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Abcd1
Location:
ChrX:73716597-73738534 bp, + strand
Genetic Position: ChrX,
37.39 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:44812
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment consisting of a large part of exon 1 was deleted and replaced with a neomycin selection cassette. These sequences encode the translation initiation site and the first four transmembrane domains. A mutated transcript is produced from this allele, but lacks the authentic translation start site and contains stop codons in all three reading frames. (J:44812)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:44812
Forss-Petter S et al.,
"Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice."
J Neurosci Res 1997 Dec 1;50(5):829-43
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All: |
4 reference(s)
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Analysis Tools
