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| Nomenclature |
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Symbol:
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Wastm1Sbs
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Name:
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Wiskott-Aldrich syndrome homolog (human);
targeted mutation 1, Scott B Snapper
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MGI ID: |
MGI:1861707 |
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Synonyms: |
Was-, wasp- |
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Gene:
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Was
Location:
ChrX:8081453-8090498 bp, - strand
Genetic Position: ChrX,
3.65 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:48836
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin cassette was inserted into exon 7, which encodes part of the GTPase-binding domain. The absence of transcript and protein produced from the targeted allele in male hemizygous mutant mice was confirmed by Northern blot and Western blot analyses.(J:48836)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:48836
Snapper SB et al.,
"Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation."
Immunity 1998 Jul;9(1):81-91
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All: |
52 reference(s)
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Analysis Tools
