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| Nomenclature |
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Symbol:
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Fanclgcd
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Name:
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Fanconi anemia, complementation group L;
germ cell deficient
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MGI ID: |
MGI:1861640 |
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Synonyms: |
gcd, Phf9gcd |
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Gene:
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Fancl
Location:
Chr11:26386135-26471876 bp, + strand
Genetic Position: Chr11,
15.85 cM, cytoband A2-A3
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Histological sections of adult Fanclgcd/Fanclgcd mouse gonads
Show the 3 image(s) involving this allele.
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Transgene
origin |
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Strain of Origin:
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(CBA/J x C57BL/6J)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutations: | |
Insertion, Intergenic deletion |
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Mutation details: This mutation was identified as a transgene insertion that also deletes approximately 150 kb of genomic sequence at the insertion site. This deletion removes exons 4-14 of Fancl and also removes exons 2-11 of a neighboring gene Vrk2. The transgene contains a fragment of goat DNA. A transgene expressing Vrk2 that was introduced into homozygous mice failed to rescue the phenotype, suggesting that the deletion of Fancl was solely responsible for the phenotype seen in these mice. (J:80424)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fancl Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:21254
Pellas TC et al.,
"Germ-cell deficient (gcd), an insertional mutation manifested as infertility in transgenic mice."
Proc Natl Acad Sci U S A 1991 Oct 1;88(19):8787-91
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All: |
5 reference(s)
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Analysis Tools
