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| Nomenclature |
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Symbol:
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CrygsOpj
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Name:
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crystallin, gamma S;
opacity due to poor secondary fiber cell junctions
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MGI ID: |
MGI:1861635 |
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Synonyms: |
ENU-410 |
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Gene:
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Crygs
Location:
Chr16:22805203-22811410 bp, - strand
Genetic Position: Chr16,
13.66 cM
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Progressive cataract development in CrygsOpj/Crygs+ and CrygsOpj/CrygsOpj mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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(101 x C3H)F1
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: A single base pair mutation (T to C) in exon 2 replaces Phe with Ser at amino acid position 9 of the protein. The mutant protein shows a concentration dependent decrease in solubility and a loss of secondary structure at near-physiological temperatures. (J:68109)
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Inheritance: | |
Semidominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:21950
Favor J,
"A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea."
Mutat Res 1983 Aug;110(2):367-82
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All: |
4 reference(s)
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Analysis Tools
