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| Nomenclature |
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Symbol:
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ShhDsh
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Name:
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sonic hedgehog;
short digits
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MGI ID: |
MGI:1861186 |
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Synonyms: |
Dsh, short digits |
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Gene:
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Shh
Location:
Chr5:28456815-28467101 bp, - strand
Genetic Position: Chr5,
14.39 cM
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Mutation
origin |
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Strain of Origin:
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(101 x C3H)F1
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Mutation
description |
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Allele
Type: | |
Radiation induced |
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Mutation: | |
Inversion |
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Mutation details: The short digits mutation was shown to be allelic to Shh mutations by an alleleism test (Stefan Mundlos, unpublished, see also J:67151). This mutation is an inversion comprising 11.7 Mb. The distal breakpoint is 13.298 kb upstream of Shh, separating the coding sequence from several putative regulatory elements. The inversion results in dysregulated expression of Shh resulting in the mutant phenotype. (J:97323)
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Inheritance: | |
Semidominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Shh Mutation:
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21 strains or lines available |
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| References |
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Original: |
J:14105
Selby P et al.,
"Short digits, a new mutation."
Mouse News Lett 1986;75():43
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All: |
5 reference(s)
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Analysis Tools
