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| Nomenclature |
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Symbol:
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Hfm
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Name:
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hemifacial microsomia-associated locus
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MGI ID: |
MGI:1861103 |
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Synonyms: |
643-7, microtia, Tg(MBP)643Mok |
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Gene:
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Hfm
Location:
unknown
Genetic Position: Chr10,
cytoband B1-3
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Transgene
origin |
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Strain of Origin:
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SWV-Mbpshi
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutations: | |
Deletion, Insertion |
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Mutation details: A 23 Kb deletion on chromosome 10 occurred at the integration site of a transgene that expressed myelin basic protein. (J:21097)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Hfm Mutation:
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0 strains or lines available |
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Notes |
This mutation was generated by by pronuclear injection of a transgene into SWV-Mbpshi fertilized oocytes. Approximately 50-100 copies initially inserted into this locus, but the copy number decreased to 1 or a few during the course of breeding. This decrease of copy number had no effect on the phenotype. Some mice were mated to a B6C female to expand to an F3 generation.
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| References |
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Original: |
J:77548
Kimura M et al.,
"Restoration of myelin formation by a single type of myelin basic protein in transgenic shiverer mice."
Proc Natl Acad Sci U S A 1989 Jul;86(14):5661-5
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All: |
3 reference(s)
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Analysis Tools
