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| Nomenclature |
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Symbol:
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Tfamtm1Lrsn
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Name:
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transcription factor A, mitochondrial;
targeted mutation 1, Nils-Goran Larsson
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MGI ID: |
MGI:1860962 |
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Synonyms: |
TfamloxP |
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Gene:
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Tfam
Location:
Chr10:71225464-71238280 bp, - strand
Genetic Position: Chr10,
36.83 cM, cytoband B5
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Skeletal muscle analysis of Tfamtm1Lrsn/Tfamtm1Lrsn Myl1tm1(cre)Sjb/Myl1+ mice
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:46387
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A single loxP site was inserted 5' to exon 6 and a PCK-neomycin selection cassette followed by an additional loxP site was inserted 3' to exon 7. The insertions did not have any effect on the normal expression of the gene (data not shown). (J:46387)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tfam Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:46387
Larsson NG et al.,
"Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice [see comments]"
Nat Genet 1998 Mar;18(3):231-6
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All: |
31 reference(s)
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Analysis Tools
