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| Nomenclature |
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Symbol:
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Tfamtm1.1Lrsn
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Name:
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transcription factor A, mitochondrial;
targeted mutation 1.1, Nils-Goran Larsson
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MGI ID: |
MGI:1860956 |
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Synonyms: |
Tfam- |
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Gene:
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Tfam
Location:
Chr10:71225464-71238280 bp, - strand
Genetic Position: Chr10,
36.83 cM, cytoband B5
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Tfamtm1.1Lrsn/Tfamtm1.1Lrsn mice display massive apoptosis at E9.5
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:46387
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: This allele is a derivative of Tfamtm1Lrsn in which the loxP flanked sequences were removed in the germline by Cre mediated recombination. Mice carrying the Tfamtm1Lrsn allele were mated to mice carrying the TgN(ACTB-Cre)2Mrt transgene to produce progeny in which the loxP flanked sequences were deleted. (J:46387)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tfam Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:46387
Larsson NG et al.,
"Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice [see comments]"
Nat Genet 1998 Mar;18(3):231-6
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All: |
3 reference(s)
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Analysis Tools
