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| Nomenclature |
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Symbol:
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Pkd2tm2Som
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Name:
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polycystic kidney disease 2;
targeted mutation 2, Stefan Somlo
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MGI ID: |
MGI:1860866 |
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Synonyms: |
null allele, Pkd2-, WS183 |
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Gene:
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Pkd2
Location:
Chr5:104459450-104505819 bp, + strand
Genetic Position: Chr5,
50.68 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:47035
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Parent Cell Line:
| WW6 (ES Cell) |
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Strain of Origin:
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STOCK 129/Sv and C57BL/6J and SJL
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Exon 1 was disrupted by the insertion of a selectable Neo cassette in the same transcriptional orientation as the gene. This allele is a a presumed true null as opposed to WS25 which is an apparent hypomorphic allele. (J:59314)
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Inheritance: | |
Semidominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pkd2 Mutation:
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22 strains or lines available |
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| References |
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Original: |
J:47035
Wu G et al.,
"Somatic inactivation of Pkd2 results in polycystic kidney disease."
Cell 1998 Apr 17;93(2):177-88
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All: |
25 reference(s)
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Analysis Tools
