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| Nomenclature |
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Symbol:
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Tlr4lps-del
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Name:
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toll-like receptor 4;
defective lipopolysaccharide response, deletion
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MGI ID: |
MGI:1860755 |
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Synonyms: |
Tlr4-, TLR4-KO, TLR4lps- |
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Gene:
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Tlr4
Location:
Chr4:66827584-66930284 bp, + strand
Genetic Position: Chr4,
34.66 cM
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Mutation
origin |
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Strain of Origin:
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C57BL/10ScN
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Intragenic deletion |
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Mutation details: This allele has been characterized by lack of mRNA owing to a deletion of the locus. 74723bp of genomic DNA sequence have been removed, apparently encompasing only the Tlr4 gene. (J:51522, J:122203)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
C57BL/10ScN, C57BL/10ScNJ, and C57BL10/ScCr mice carry this allele.
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| References |
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Original: |
J:6086
Vogel SN et al.,
"Characterization of a congenitally LPS-resistant, athymic mouse strain."
J Immunol 1979 Feb;122(2):619-22
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All: |
159 reference(s)
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Analysis Tools
