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| Nomenclature |
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Symbol:
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Tsk2
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Name:
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tight skin 2
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MGI ID: |
MGI:1860700 |
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Gene:
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Tsk2
Location:
unknown
Genetic Position: Chr1,
Syntenic
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Mutation
origin |
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Mutation
description |
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Allele
Type: |
Chemically induced (ENU) |
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Inheritance: |
Semidominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
This mutation was found among offspring of a 101/H male treated with 200 mg/kg ethylnitrosourea (ENU), and shown to be a second tight skin mutation (see Fbn1Tsk). Homozygotes probably die prenatally (J:14073). Heterozygotes can be recognized at 1 to 2 weeks of age by tightness of the skin over the shoulders when picked up. No other abnormality was detected and the mice are fully viable and fertile. Histological examination of the skin of these mice reveals accumulation of collagen and mononuclear cell infiltration in dermis and adipose tissue. An increased collagen content is found biochemically, and steady-state levels of Col1a1 mRNA. These abnormalities resemble those of human patients with systemic sclerosis (J:31216).
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| References |
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Original: |
J:14073
Peters J et al.,
"Tight skin-2 (Tsk-2)"
Mouse News Lett 1986;74():91-2
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All: |
6 reference(s)
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Analysis Tools
