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| Nomenclature |
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Symbol:
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Adrb3tm1Lowl
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Name:
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adrenergic receptor, beta 3;
targeted mutation 1, Bradford B Lowell
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MGI ID: |
MGI:1860610 |
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Synonyms: |
beta3-AR - |
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Gene:
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Adrb3
Location:
Chr8:27225776-27229588 bp, - strand
Genetic Position: Chr8,
15.94 cM, cytoband A2-A4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:30060
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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FVB/N
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 306bp genomic fragment containing the sequences encoding the third through the fifth transmembrane domains was replaced with a neomycin selection cassette. An RNase protection assay demonstrated that the encoded transcript was not detectable in brown adipose tissue of homozygous mice. (J:30060)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
This allele was generated by direct injection of DNA vectors into FVB/N zygotes. (J:30060)
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| References |
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Original: |
J:30060
Susulic VS et al.,
"Targeted disruption of the beta 3-adrenergic receptor gene."
J Biol Chem 1995 Dec 8;270(49):29483-92
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All: |
27 reference(s)
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Analysis Tools
