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| Nomenclature |
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Symbol:
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Thratm1Ven
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Name:
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thyroid hormone receptor alpha;
targeted mutation 1, Bjorn Vennstrom
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MGI ID: |
MGI:1860441 |
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Synonyms: |
TRalpha1 -, TRalpha1 KO |
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Gene:
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Thra
Location:
Chr11:98740638-98769006 bp, + strand
Genetic Position: Chr11,
62.58 cM, cytoband D-E
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:45675
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A gene targeting construct was designed to disrupt the alpha1 isoform, while maintaining the integrity of the alpha2 isoform, as well as the of the orphan hormone receptor rev-erbAalpha that is transcribed on the opposite strand. RT-PCR was used to confirm these results. (J:45675)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:45675
Wikstrom L et al.,
"Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1."
EMBO J 1998 Jan 15;17(2):455-61
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All: |
39 reference(s)
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Analysis Tools
