|
|
| Nomenclature |
|
Symbol:
|
Tnfrsf1btm1Imx
|
|
Name:
|
tumor necrosis factor receptor superfamily, member 1b;
targeted mutation 1, Immunex Research and Development Corporation
|
|
MGI ID: |
MGI:1860087 |
|
Synonyms: |
p75-, p75 KO, TNFbeta ko, TNFR2-, TNFRII-, Tnfrsf1btm1Imx |
|
Gene:
|
Tnfrsf1b
Location:
Chr4:145213463-145246870 bp, - strand
Genetic Position: Chr4,
78.17 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:45147
|
|
Parent Cell Line:
| AB1 (ES Cell) |
|
Strain of Origin:
|
129S7/SvEvBrd-Hprt+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: A PGK-neomycin resistance cassette replaced 1kb of sequence encoding amino acids 3 - 26. Lack of gene product was shown functionally. (J:45147)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:45147
Peschon JJ et al.,
"TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation."
J Immunol 1998 Jan 15;160(2):943-52
|
|
All: |
173 reference(s)
|
|
Analysis Tools
