|
|
| Nomenclature |
|
Symbol:
|
Tulp1tm1Pjn
|
|
Name:
|
tubby like protein 1;
targeted mutation 1, Patsy M Nishina
|
|
MGI ID: |
MGI:1859921 |
|
Synonyms: |
Tulp1- |
|
Gene:
|
Tulp1
Location:
Chr17:28351515-28365182 bp, - strand
Genetic Position: Chr17,
14.66 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:59884
|
|
Parent Cell Line:
| RW-4 (ES Cell) |
|
Strain of Origin:
|
129X1/SvJ
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: Exons 8 and 9 were replaced by a neomycin selection cassette. Western blot analysis revealed an absence of encoded protein in the retinas and brains and brains of homozygous mutant mice. Immunofluorescence analysis of retinal tissue confirmed the blotting analysis. (J:59884, J:79602)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:59884
Ikeda S et al.,
"Retinal degeneration but not obesity is observed in null mutants of the tubby-like protein 1 gene."
Hum Mol Genet 2000 Jan 22;9(2):155-63
|
|
All: |
6 reference(s)
|
|
Analysis Tools
