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| Nomenclature |
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Symbol:
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Mettm1Cpo
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Name:
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met proto-oncogene;
targeted mutation 1, Carola Ponzetto
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MGI ID: |
MGI:1858019 |
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Synonyms: |
Met-, metd, MetD |
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Gene:
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Met
Location:
Chr6:17463800-17573980 bp, + strand
Genetic Position: Chr6,
7.83 cM, cytoband A2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:36244
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A mutant human cDNA coding for the transmembrane and cytoplasmic domain of the receptor was inserted in-frame into mouse genomic sequences. The cDNA was followed by a neomycin resistance cassette. A fusion protein consisting of the murine extracellular domain fused to the human transmembrane and cytoplasmic domain carrying the mutations Y1349F and Y1356Fis produced from this allele.
(J:36244)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Met Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:36244
Maina F et al.,
"Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development."
Cell 1996 Nov 1;87(3):531-42
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All: |
12 reference(s)
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Analysis Tools
