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| Nomenclature |
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Symbol:
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Csrp3tm1Crni
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Name:
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cysteine and glycine-rich protein 3;
targeted mutation 1, Pico Caroni
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MGI ID: |
MGI:1858015 |
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Synonyms: |
MLP- |
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Gene:
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Csrp3
Location:
Chr7:48830398-48848051 bp, - strand
Genetic Position: Chr7,
31.11 cM, cytoband B3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:38213
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 2. Northern blot analysis on RNA derived from heart of homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on extracts derived from heart tissue confirmed that no stable protein was made from this allele. (J:38213)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Csrp3 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:38213
Arber S et al.,
"MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure."
Cell 1997 Feb 7;88(3):393-403
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All: |
27 reference(s)
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Analysis Tools
