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| Nomenclature |
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Symbol:
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Soat1tm1Far
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Name:
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sterol O-acyltransferase 1;
targeted mutation 1, Bob Farese
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MGI ID: |
MGI:1857978 |
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Synonyms: |
Acact-, Acat-1- |
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Gene:
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Soat1
Location:
Chr1:156428108-156474328 bp, - strand
Genetic Position: Chr1,
67.71 cM
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Adrenal lipid depletion in Soat1tm1Far/Soat1tm1Far mice
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:37049
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Parent Cell Line:
| RF8 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Insertion of a neomycin cassette into a 5' early exon (amino acids 50-100). Reduced levels of a truncated mRNA transcript were detected by Northern blot on RNA from preputial glands. No protein was detected by immunoblot analysis in homogenates from preputial glands, ovaries and adrenals. (J:37049)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:37049
Meiner VL et al.,
"Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals."
Proc Natl Acad Sci U S A 1996 Nov 26;93(24):14041-6
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All: |
11 reference(s)
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Analysis Tools
