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| Nomenclature |
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Symbol:
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Apctm1Mmt
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Name:
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adenomatosis polyposis coli;
targeted mutation 1, Makoto M Taketo
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MGI ID: |
MGI:1857957 |
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Synonyms: |
Apcd716, Apcdelta716 |
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Gene:
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Apc
Location:
Chr18:34220924-34318608 bp, + strand
Genetic Position: Chr18,
18.53 cM
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Nascent intestinal polyps in Apctm1Mmt/Apc+ mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:25200
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into exon 15 at nucleotide 2150. This mutation is predicted to cause premature truncation of the protein at codon 716. (J:25200)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Apc Mutation:
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50 strains or lines available |
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| References |
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Original: |
J:25200
Oshima M et al.,
"Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene."
Proc Natl Acad Sci U S A 1995 May 9;92(10):4482-6
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All: |
35 reference(s)
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Analysis Tools
