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| Nomenclature |
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Symbol:
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Bmp8btm1Blh
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Name:
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bone morphogenetic protein 8b;
targeted mutation 1, Brigid L Hogan
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MGI ID: |
MGI:1857954 |
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Gene:
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Bmp8b
Location:
Chr4:123105165-123132099 bp, + strand
Genetic Position: Chr4,
57.38 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:34057
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 7 kb genomic fragment containing exon 4 was replaced with a neomycin selection cassette. The deleted sequences encode the conserved dibasic proteolytic cleavage site between the pro- and mature regions of the encoded protein. In situ hybridization experiments on sections of testis of homozygous male mice confirmed that no detectable transcript was produced from this allele. (J:34057)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+) or TL1 (129S6/SvEvTac).
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| References |
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Original: |
J:34057
Zhao GQ et al.,
"The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse."
Genes Dev 1996 Jul 1;10(13):1657-69
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All: |
7 reference(s)
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Analysis Tools
