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| Nomenclature |
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Symbol:
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Bmp8atm1Blh
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Name:
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bone morphogenetic protein 8a;
targeted mutation 1, Brigid L Hogan
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MGI ID: |
MGI:1857953 |
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Synonyms: |
Bmp8a-, Bmp8atm1 |
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Gene:
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Bmp8a
Location:
Chr4:123312645-123343252 bp, - strand
Genetic Position: Chr4,
57.42 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:46927
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Parent Cell Line:
| TL1/TL-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: An 8 kb genomic fragment containing exons 4-6 was replaced with a neomycin selection cassette. In situ hybridization experiments on spermatids in testes of homozygous male mice demonstrated that an aberrant transcript is produced from this allele, but no functional protein is predicted to be produced from this allele since the majority of the coding sequences were deleted. (J:46927)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Bmp8a Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:46927
Zhao GQ et al.,
"Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis."
Development 1998 Mar;125(6):1103-12
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All: |
3 reference(s)
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Analysis Tools
