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| Nomenclature |
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Symbol:
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Apctm1Rak
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Name:
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adenomatosis polyposis coli;
targeted mutation 1, Raju Kucherlapati
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MGI ID: |
MGI:1857951 |
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Synonyms: |
APC1638, Apc1638N, APC1638N |
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Gene:
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Apc
Location:
Chr18:34220924-34318608 bp, + strand
Genetic Position: Chr18,
18.53 cM
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Microadenoma in Mbd4tm1Wed/Mbd4tm1Wed Apctm1Rak/Apc+ gastrointestinal tract
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:20443
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into exon 15 at a site corresponding to codon 1638. This mutation is predicted to result in a truncated protein. RT-PCR analysis detected a mutated transcript produced from this allele, but a truncated protein was not consistently detected by Western blot analysis. (J:20443)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:20443
Fodde R et al.,
"A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors."
Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73
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All: |
75 reference(s)
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Analysis Tools
