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| Nomenclature |
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Symbol:
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Tcirg1tm1Ypl
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Name:
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T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3;
targeted mutation 1, Yi Ping Li
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MGI ID: |
MGI:1857950 |
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Synonyms: |
Atp6i- |
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Gene:
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Tcirg1
Location:
Chr19:3896050-3907133 bp, - strand
Genetic Position: Chr19,
3.62 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:58795
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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A PGK-neomycin resistance cassette replaced 3.0kb of sequence including exons 2-5. (J:58795)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tcirg1 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:58795
Li YP et al.,
"Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification."
Nat Genet 1999 Dec;23(4):447-51
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All: |
2 reference(s)
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Analysis Tools
