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| Nomenclature |
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Symbol:
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Ptentm1Ppp
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Name:
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phosphatase and tensin homolog;
targeted mutation 1, Pier Paolo Pandolfi
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MGI ID: |
MGI:1857936 |
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Synonyms: |
PTEN- |
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Gene:
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Pten
Location:
Chr19:32757497-32826160 bp, + strand
Genetic Position: Chr19,
28.14 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:49532
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 4 and 5, which contain sequences encoding the phosphatase domain. (J:49532)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pten Mutation:
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36 strains or lines available |
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| References |
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Original: |
J:49532
Di Cristofano A et al.,
"Pten is essential for embryonic development and tumour suppression."
Nat Genet 1998 Aug;19(4):348-55
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All: |
41 reference(s)
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Analysis Tools
