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| Nomenclature |
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Symbol:
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Ptch1tm1Zim
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Name:
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patched homolog 1;
targeted mutation 1, Andreas Zimmer
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MGI ID: |
MGI:1857935 |
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Synonyms: |
Ptc1-, Ptc1neo67, ptchneo67, ptcneo67 |
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Gene:
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Ptch1
Location:
Chr13:63511533-63565520 bp, - strand
Genetic Position: Chr13,
32.8 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:47421
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Parent Cell Line:
| MPI-II (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
| |
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Mutation details: Exons 6 and 7 were replaced by the insertion of neomycin selection cassette. Southern blot analysis confirmed the targeting event. (J:47421)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:47421
Hahn H et al.,
"Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome [see comments]"
Nat Med 1998 May;4(5):619-22
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All: |
30 reference(s)
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Analysis Tools
