|
|
| Nomenclature |
|
Symbol:
|
Mmp7tm1Lmm
|
|
Name:
|
matrix metallopeptidase 7;
targeted mutation 1, Lynn M Matrisian
|
|
MGI ID: |
MGI:1857932 |
|
Synonyms: |
MAT-, mmp-7-, mmp7-, MMP7-, Mmp7tm1vu |
|
Gene:
|
Mmp7
Location:
Chr9:7692090-7699585 bp, + strand
Genetic Position: Chr9,
2.46 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:38609
|
|
Parent Cell Line:
| R1 (ES Cell) |
|
Strain of Origin:
|
(129X1/SvJ x 129S1/Sv)F1-Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: A neomycin resistance cassette replaced approximately 95 nucleotides of coding sequence in exon 4 of the gene. No transcript for the targeted gene was detectable by Northern blot analysis of RNA from the small intestine of homozygous mutant mice. (J:38609)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:38609
Wilson CL et al.,
"Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin."
Proc Natl Acad Sci U S A 1997 Feb 18;94(4):1402-7
|
|
All: |
37 reference(s)
|
|
Analysis Tools
