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| Nomenclature |
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Symbol:
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Gjb1tm1Kwi
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Name:
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gap junction protein, beta 1;
targeted mutation 1, Klaus Willecke
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MGI ID: |
MGI:1857927 |
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Synonyms: |
Cx32- |
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Gene:
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Gjb1
Location:
ChrX:101376378-101385629 bp, + strand
Genetic Position: ChrX,
44.06 cM, cytoband D-F4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:36146
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into exon 2 of the gene, resulting in a stop codon 90 nucleotides after the translational start and a new start codon 15 base pairs further downstream. Northern blots of total liver RNA from homozygous mutant mice showed no detectable transcript for the gene. (J:36146)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:36146
Nelles E et al.,
"Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice."
Proc Natl Acad Sci U S A 1996 Sep 3;93(18):9565-70
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All: |
53 reference(s)
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Analysis Tools
