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| Nomenclature |
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Symbol:
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Cftrtm3Bay
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Name:
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cystic fibrosis transmembrane conductance regulator;
targeted mutation 3, Baylor College of Medicine
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MGI ID: |
MGI:1857898 |
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Synonyms: |
cftrm3Bay |
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Gene:
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Cftr
Location:
Chr6:18170687-18322768 bp, + strand
Genetic Position: Chr6,
8.1 cM, cytoband A3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:29656
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Parent Cell Line:
| AB2.1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: Sequences in exon 2 were mutated to create an in frame stop codon and a neomycin resistance cassette was inserted in reverse transcriptional orientation into intron 1 of the gene. (J:29656)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cftr Mutation:
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13 strains or lines available |
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| References |
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Original: |
J:29656
Hasty P et al.,
"Severe phenotype in mice with termination mutation in exon 2 of cystic fibrosis gene."
Somat Cell Mol Genet 1995 May;21(3):177-87
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All: |
3 reference(s)
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Analysis Tools
