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| Nomenclature |
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Symbol:
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Aldh1a2tm1Ipc
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Name:
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aldehyde dehydrogenase family 1, subfamily A2;
targeted mutation 1, Pierre Chambon
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MGI ID: |
MGI:1857891 |
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Synonyms: |
Raldh2- |
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Gene:
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Aldh1a2
Location:
Chr9:71215789-71296243 bp, + strand
Genetic Position: Chr9,
39.85 cM
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Abnormal development of laryngeal and tracheal cartilages in Aldh1a2tm1Dll/Aldh1a2tm1Ipc and Aldh1a2tm1Dll/Aldh1a2tm1Dll mice and absence of thymus and parathyroid glands in Aldh1a2tm1Dll/Aldh1a2tm1Ipc mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:54067
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomcycin selection cassette was inserted into the fourth exon of the gene at codon 140. This mutation is predicted to cause a premature truncation of the protein before the enzyme active site. (J:54067)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Aldh1a2 Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:54067
Niederreither K et al.,
"Embryonic retinoic acid synthesis is essential for early mouse post-implantation development [see comments]"
Nat Genet 1999 Apr;21(4):444-8
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All: |
33 reference(s)
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Analysis Tools
