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| Nomenclature |
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Symbol:
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Drd2tm1Low
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Name:
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dopamine receptor D2;
targeted mutation 1, Malcolm J Low
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MGI ID: |
MGI:1857875 |
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Synonyms: |
D2-, D2KO, D2 KO, D2R-, Drd2- |
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Gene:
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Drd2
Location:
Chr9:49340662-49407214 bp, + strand
Genetic Position: Chr9,
26.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:41858
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment containing exon 7 and part of exon 8 was replaced by a neomycin resistance cassette. (J:41858)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Unlike mice homozygous for Drd2tm1Ebo mice do not display Phenotypic Similarity to Human Syndrome: Parkinson Disease (J:47001)
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| References |
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Original: |
J:41858
Kelly MA et al.,
"Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice."
Neuron 1997 Jul;19(1):103-13
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All: |
63 reference(s)
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Analysis Tools
