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| Nomenclature |
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Symbol:
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Msr1tm1Csk
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Name:
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macrophage scavenger receptor 1;
targeted mutation 1, Chugai Pharmaceutical Co, Ltd
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MGI ID: |
MGI:1857874 |
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Synonyms: |
MSR-, Msr1-KO, Msr1tm1Kod, Scvrtm1, SR-, Sra-, SR-A-, SR-AI/II KO, SRAKO, SRKO |
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Gene:
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Msr1
Location:
Chr8:39581700-39642678 bp, - strand
Genetic Position: Chr8,
23.89 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:39079
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Parent Cell Line:
| A3-1 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin cassette was inserted into the EcoRI site in exon 4, which encodes the alpha helical coiled-coil structure essential for the formation of functional trimeric receptors. Protein was not detectable by immunostaining of liver sections from homozygous mutant animals. (J:39079)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:39079
Suzuki H et al.,
"A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection."
Nature 1997 Mar 20;386(6622):292-6
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All: |
87 reference(s)
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Analysis Tools
