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| Nomenclature |
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Symbol:
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Pitx2tm2Sac
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Name:
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paired-like homeodomain transcription factor 2;
targeted mutation 2, Sally Camper
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MGI ID: |
MGI:1857846 |
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Synonyms: |
Pitx2-, Pitx2null |
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Gene:
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Pitx2
Location:
Chr3:129199878-129219591 bp, + strand
Genetic Position: Chr3,
57.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:51160
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: This allele is derived from Pitx2tm1 which was produced by gene targeting with a vector engineered to contain a loxP site downstream from exon 4 and a floxed neomycin cassette upstream of exon 4. Subsequent cre expression resulted in deletion of both the neo selection cassette and exon 4. This allele is a demonstrated to be a functional null. (J:51160)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pitx2 Mutation:
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12 strains or lines available |
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| References |
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Original: |
J:51160
Gage PJ et al.,
"Dosage requirement of Pitx2 for development of multiple organs."
Development 1999 Oct;126(20):4643-51
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All: |
24 reference(s)
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Analysis Tools
