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| Nomenclature |
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Symbol:
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Shhtm1Chg
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Name:
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sonic hedgehog;
targeted mutation 1, Chin Chiang
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MGI ID: |
MGI:1857796 |
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Synonyms: |
Shh- |
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Gene:
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Shh
Location:
Chr5:28456815-28467101 bp, - strand
Genetic Position: Chr5,
14.39 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:35802
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK neomycin cassette replaced exon 2 and portions of the flanking intronic sequences in the Shh gene. (J:35802)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Shh Mutation:
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21 strains or lines available |
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| References |
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Original: |
J:35802
Chiang C et al.,
"Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function."
Nature 1996 Oct 3;383(6599):407-13
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All: |
131 reference(s)
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Analysis Tools
