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| Nomenclature |
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Symbol:
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Cnr1tm1Zim
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Name:
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cannabinoid receptor 1 (brain);
targeted mutation 1, Andreas Zimmer
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MGI ID: |
MGI:1857762 |
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Synonyms: |
Cb1-, CB1neor, CB1R KO, Cnr1- |
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Gene:
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Cnr1
Location:
Chr4:33924593-33948831 bp, + strand
Genetic Position: Chr4,
16.28 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:54995
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Parent Cell Line:
| MPI-II (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: This Cnr1 mutation was created by gene targeting in which a neo cassette replaced amino acids 33-447 of the coding region (J:54995). A neomycin resistance cassette replaced genomic sequence coding for amino acids 33-447, corresponding to most of the coding sequence of the gene. Absence of the encoded protein in homozygous animals was confirmed by receptor binding studies. (J:54995)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:54995
Zimmer A et al.,
"Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice [see comments]"
Proc Natl Acad Sci U S A 1999 May 11;96(10):5780-5
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All: |
73 reference(s)
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Analysis Tools
