Slc11a1s
Spontaneous Allele Detail
|
|
| Nomenclature |
|
Symbol:
|
Slc11a1s
|
|
Name:
|
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1;
pathogen susceptibility (Bcg/Ity/Lsh)
|
|
MGI ID: |
MGI:1857755 |
|
Synonyms: |
Bcgs, Itys, Lshs, Nramp1-, Nramp1Asp169, Nramp1D169 |
|
Gene:
|
Slc11a1
Location:
Chr1:74375203-74386062 bp, + strand
Genetic Position: Chr1,
38.54 cM
|
|
Mutation
origin |
|
Strain of Origin:
|
multiple strains
|
|
Mutation
description |
|
Allele
Type: | |
Spontaneous |
|
Mutation: | |
Single point mutation |
| |
|
Mutation details: This allele is associated with susceptibility to infection with diverse pathogens, including several Mycobacterium species, Salmonella typhimurium, and Leishmania donovani. In this allele a G to A transition results in a non-conservative replacement of Gly to Asp at position 105 within the second predicted transmembrane domain of the protein. The protein carries another non-conservative replacement of Gly to Asp at position 169 within the fourth predicted transmembrane domain. (J:4762, J:20139, J:35004)
|
|
Inheritance: | |
Recessive |
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Slc11a1 Mutation:
|
3 strains or lines available |
|
|
Notes |
Cation concentrations would be elevated in macrophages from mice carrying mutations that alter Slc11a1 transport function, i.e. the Slc11a1s allele, rendering susceptibility to infection (J:50686). This model is supported by the observation that mice normally resistant to Mycobacterium avium infection loose their advantage over Slc11a1s mice when exposed to an excess of iron (J:50686).
Strains carrying this allele include BALB/cJ, C57BL/6J, C57BL/10J, DBA/1J, SWV, NZW/LacJ, MOLF/Ei.
|
| References |
|
Original: |
J:24667
Webster LT,
"Inherited and acquired factors in resistance to infection. I. Development of resistant and susceptible lines of mice through selective breeding"
J Exp Med 1933;57():793-843
|
|
All: |
52 reference(s)
|
|
|
Analysis Tools
