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| Nomenclature |
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Symbol:
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Cnr1tm1Map
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Name:
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cannabinoid receptor 1 (brain);
targeted mutation 1, Marc Parmentier
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MGI ID: |
MGI:1857736 |
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Synonyms: |
CB1 KO, CB1-KO, CB1r-, Cnr1- |
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Gene:
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Cnr1
Location:
Chr4:33924593-33948831 bp, + strand
Genetic Position: Chr4,
16.28 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:52188
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin cassette replaced a genomic fragment containing sequences encoding the first 233 codons of the gene. Northern blot analysis demonstrated the absence of transcripts from this gene in brain and testis of homozygous mice and binding assays confirmed the absence of active protein. (J:52188)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:52188
Ledent C et al.,
"Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice."
Science 1999 Jan 15;283(5400):401-4
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All: |
64 reference(s)
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Analysis Tools
