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| Nomenclature |
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Symbol:
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Lig4tm1Icrf
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Name:
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ligase IV, DNA, ATP-dependent;
targeted mutation 1, Imperial Cancer Research Fund
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MGI ID: |
MGI:1857720 |
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Synonyms: |
lig4- |
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Gene:
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Lig4
Location:
Chr8:9970020-9976323 bp, - strand
Genetic Position: Chr8,
4.52 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:51608
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced the DNA sequence encoding amino acids 142 - 605 of the protein. (J:51608)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lig4 Mutation:
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10 strains or lines available |
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Notes |
ES cell line = GK129 (129P2/OlaHsd) or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+).
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| References |
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Original: |
J:51608
Barnes DE et al.,
"Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice."
Curr Biol 1998 Dec 17-31;8(25):1395-8
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All: |
9 reference(s)
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Analysis Tools
