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| Nomenclature |
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Symbol:
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Tlr4Lps-d
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Name:
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toll-like receptor 4;
defective lipopolysaccharide response
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MGI ID: |
MGI:1857718 |
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Synonyms: |
lpsd, mutant TLR4, Tlr4-, Tlr4d, TLR4d, TLR4lps-def, TLR4-M, TLR4-Mu, TlrLps-d |
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Gene:
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Tlr4
Location:
Chr4:66827584-66930284 bp, + strand
Genetic Position: Chr4,
34.66 cM
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ru2l/ru2l Tlr4Lps-d/Tlr4Lps-d with littermate control
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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C3H/HeJ
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Single point mutation |
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Mutation details: This allele corresponds to a mutation in the third exon of the gene. A C to A substitution at nucleotide position 2342 results in an amino acid substitution that replaces proline with histidine at position 712.
(J:51522, J:53519, J:57938)
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Inheritance: | |
Codominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
C3H/HeJ mice carry this allele. Various combinations of Lps-associated traits have been followed in crosses between C3H/HeJ and other C3H substrains, and the traits have in all cases segregated together (J:30692, J:5557, J:5593, J:5938). Some of the traits show dominance of the Tlr4lps-n allele; others, including Tlr4Lps-d, show codominance.
Genbank ID for this allele: AF095353
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| References |
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Original: |
J:5721
Dumont F et al.,
"Electrokinetic properties of splenic lymphocytes from the low-lipopolysaccharide responder C3H/Hej mice."
Folia Biol (Praha) 1976;12(3):145-50
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All: |
285 reference(s)
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Analysis Tools
