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| Nomenclature |
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Symbol:
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Flt1tm1Jrt
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Name:
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FMS-like tyrosine kinase 1;
targeted mutation 1, Janet Rossant
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MGI ID: |
MGI:1857717 |
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Synonyms: |
Flt-1-, Flt-1lacZ, Flt1lacZ, flt-1lcz, VEGFR1-lacZ |
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Gene:
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Flt1
Location:
Chr5:147561604-147726011 bp, - strand
Genetic Position: Chr5,
87.01 cM, cytoband G
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:26845
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A LacZ-neomycin resistance cassette replaced sequences that encode the signal peptide. The authors predict this is a null allele because the translation start site is removed and reinitiation at the first two downstream Kozak sequences would result in out-of-frame translated products. (J:26845)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:26845
Fong GH et al.,
"Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium."
Nature 1995 Jul 6;376(6535):66-70
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All: |
23 reference(s)
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Analysis Tools
