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| Nomenclature |
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Symbol:
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Vhltm1Wml
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Name:
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von Hippel-Lindau tumor suppressor;
targeted mutation 1, W Marston Linehan
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MGI ID: |
MGI:1857702 |
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Synonyms: |
VHL - |
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Gene:
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Vhl
Location:
Chr6:113623959-113631633 bp, + strand
Genetic Position: Chr6,
52.81 cM
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Placental histopathology of normal and Vhltm1Wml/Vhltm1Wml embryos
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:42486
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment containing part of exon 1, exon 2 and part of exon 3 was replaced by a neomycin expression cassette. (J:42486)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Vhl Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:42486
Gnarra JR et al.,
"Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice."
Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9102-7
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All: |
4 reference(s)
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Analysis Tools
