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| Nomenclature |
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Symbol:
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Smad4tm1Mmt
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Name:
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SMAD family member 4;
targeted mutation 1, Makoto M Taketo
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MGI ID: |
MGI:1857697 |
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Synonyms: |
Dpc4(-) |
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Gene:
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Smad4
Location:
Chr18:73639009-73703780 bp, - strand
Genetic Position: Chr18,
49.51 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:46242
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into exon 1 of the gene, truncating the peptide after 75 residues. (J:46242)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Smad4 Mutation:
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12 strains or lines available |
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Notes |
Phenotypic Similarity to Human Syndrome: colorectal adenocarcinomas (Apctm1Mmt Smad4tm1Mmt heterozygotes J:46242)
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| References |
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Original: |
J:46242
Takaku K et al.,
"Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes."
Cell 1998 Mar 6;92(5):645-56
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All: |
9 reference(s)
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Analysis Tools
