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| Nomenclature |
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Symbol:
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Smad3tm1Xfw
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Name:
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SMAD family member 3;
targeted mutation 1, Xiao Fan Wang
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MGI ID: |
MGI:1857696 |
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Synonyms: |
Smad3-, Smad3null |
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Gene:
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Smad3
Location:
Chr9:63646767-63757994 bp, - strand
Genetic Position: Chr9,
34.22 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:53948
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced the first exon and part of the first intron, including the initiating ATG codon. (J:53948)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Smad3 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:53948
Datto MB et al.,
"Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction."
Mol Cell Biol 1999 Apr;19(4):2495-504
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All: |
21 reference(s)
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Analysis Tools
