|
|
| Nomenclature |
|
Symbol:
|
Smad3tm1Cxd
|
|
Name:
|
SMAD family member 3;
targeted mutation 1, Chu-Xia Deng
|
|
MGI ID: |
MGI:1857695 |
|
Synonyms: |
Smad3-, Smad3delEx8, Smad3ex8 |
|
Gene:
|
Smad3
Location:
Chr9:63646767-63757994 bp, - strand
Genetic Position: Chr9,
34.22 cM, cytoband D
|
|
Skeletal defects in 7 month old Smad3tm1Cxd/Smad3tm1Cxd mice
Show the 3 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:53510
|
|
Parent Cell Line:
| TC1/TC-1 (ES Cell) |
|
Strain of Origin:
|
129S6/SvEvTac
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: A neomycin resistance cassette replaced exon 8 of the gene, which truncated the protein 89 amino acids from the C-terminal end. (J:53510)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Smad3 Mutation:
|
2 strains or lines available |
|
| References |
|
Original: |
J:53510
Yang X et al.,
"Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta."
EMBO J 1999 Mar 1;18(5):1280-91
|
|
All: |
95 reference(s)
|
|
Analysis Tools
