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| Nomenclature |
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Symbol:
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Tgfb1tm1N
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Name:
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transforming growth factor, beta 1;
targeted mutation 1, National Institutes of Health
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MGI ID: |
MGI:1857671 |
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Synonyms: |
Tgfb1-, TGF-beta1- |
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Gene:
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Tgfb1
Location:
Chr7:25687002-25705077 bp, + strand
Genetic Position: Chr7,
13.98 cM
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Histopathological analysis on lung and heart tissues of Tgfb1tm1N/Tgfb1tm1N mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:50848
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Part of the first exon and intron was replaced by a phosphoglycerate kinase-neomycin resistance gene. (J:18881, J:50848)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tgfb1 Mutation:
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13 strains or lines available |
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| References |
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Original: |
J:50848
Kulkarni AB et al.,
"Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death."
Proc Natl Acad Sci U S A 1993 Jan 15;90(2):770-4
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All: |
61 reference(s)
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Analysis Tools
