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| Nomenclature |
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Symbol:
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Phc1tm1Os
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Name:
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polyhomeotic-like 1 (Drosophila);
targeted mutation 1, Osaka University Medical School
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MGI ID: |
MGI:1857629 |
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Synonyms: |
rae28 - |
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Gene:
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Phc1
Location:
Chr6:122317738-122340506 bp, - strand
Genetic Position: Chr6,
57.52 cM, cytoband F3
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Phc1tm1Os/Phc1tm1Os hearts show abnormal cardiac looping at E9.5
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:43764
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A promoterless neomycin resistance gene was inserted in-frame into exon 4, and a fragement containing exons 5 and 6 was deleted. Western blot analysis on whole E13.5 embryo lysates confirmed that no detectable encoded protein was made in homozygous mice.(J:43764)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:43764
Takihara Y et al.,
"Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects."
Development 1997 Oct;124(19):3673-82
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All: |
9 reference(s)
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Analysis Tools
