Trp53<tm1Brd> Targeted Allele Detail MGI Mouse (MGI:1857590)

Trp53^tm1Brd
Targeted Allele Detail

Nomenclature

Symbol:	Trp53^tm1Brd
Name:	transformation related protein 53; targeted mutation 1, Allan Bradley
MGI ID:	MGI:1857590
Synonyms:	P^-, p53-, p53^N, Trp53^delta, Trp53^N, TSG-p53
Gene:	Trp53 Location: Chr11:69580359-69591873 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C

Tumor multiplicity and proliferation index in Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs, Trp53^tm1Brd/Trp53^tm1Brd and Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Trp53^tm1Brd/Trp53^tm1Brd mice

Show the 2 image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:1999
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt⁺

Mutation
description

Allele Type:		Targeted (knock-out)
Mutations:		Insertion, Intragenic deletion
		Mutation details

Phenotypes

View phenotypes for all genotypes (concatenated display).

Disease models

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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)

Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Trp53 Mutation:	135 strains or lines available

References

Original:	J:1999 Donehower LA et al., "Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours." Nature 1992 Mar 19;356(6366):215-21
All:	440 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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