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| Nomenclature |
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Symbol:
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Cftrtm1Hsc
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Name:
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cystic fibrosis transmembrane conductance regulator;
targeted mutation 1, Hospital for Sick Children
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MGI ID: |
MGI:1857545 |
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Synonyms: |
Cftrm1HSC |
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Gene:
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Cftr
Location:
Chr6:18170687-18322768 bp, + strand
Genetic Position: Chr6,
8.1 cM, cytoband A3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:31759
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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A neomycin resistance cassette was inserted into exon 1. (J:31759)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cftr Mutation:
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13 strains or lines available |
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| References |
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Original: |
J:31759
Rozmahel R et al.,
"Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor [published erratum appears in Nat Genet 1996 May;13(1):129]"
Nat Genet 1996 Mar;12(3):280-7
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All: |
4 reference(s)
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Analysis Tools
