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| Nomenclature |
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Symbol:
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Zeb1tm1Yhi
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Name:
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zinc finger E-box binding homeobox 1;
targeted mutation 1, Yujiro Higashi
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MGI ID: |
MGI:1857515 |
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Synonyms: |
deltaEF1deltaC727 |
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Gene:
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Zeb1
Location:
Chr18:5591860-5775467 bp, + strand
Genetic Position: Chr18,
4.42 cM
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Abnormal thymus architecture in Zeb1tm1Yhi/Zeb1tm1Yhi mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:39865
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The insertion of a neomycin selection cassette into exon 6 introduced a stop codon that precludes translation of the essential zinc finger DNA-binding domain. Northern blot analysis of total embryonic RNA showed the presence of longer transcripts, resulting from the insertion of neo. Western blot analysis using an anti-serum directed against the amino terminus of the encoded protein confirmed the presence of a truncated protein in extracts from homozygous mutant embryos. (J:39865)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:39865
Higashi Y et al.,
"Impairment of T cell development in deltaEF1 mutant mice."
J Exp Med 1997 Apr 21;185(8):1467-79
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All: |
5 reference(s)
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Analysis Tools
